Alterations in chromatin accessibility in ATRX-depleted cells following interferon signaling

We investigated the role of the chromatin remodeling protein ATRX on chromatin accessibility specifically upon IFN-ß stimulation utilizing stable ATRX knockdown cells. Overall design: Examination of chromatin accessibilty by ATAC-seq in human foreskin fibroblasts (ATRX knockdown and control) treated with IFN-ß.