Differential expression of keratin genes in regenerating digit of C57Bl/6 versus MRL/MpJ mice

Expression of genes encoding multiple keratin- and keratin-associated proteins varies between C57BL/6 and MRL/MpJ (superhealer) mice following digit amputation. We characterized changes in gene expression by microarray analysis of regenerating digits in these mice at various timepoints following surgical amputation. These changes were validated by quantitative rtPCR analyses. In this dataset, we include the expression data obtained from regenerating mouse digits following surgical amputation as well unamputated digits (total 24 samples). These data are used to obtain genes that are differentially expressed between the two groups of digits.编码多种角蛋白及角蛋白相关蛋白的基因的表达水平，在断指截肢后的C57BL/6与MRL/MpJ（superhealer）小鼠之间存在差异。本研究通过基因芯片（microarray）分析，对上述小鼠在手术截肢后不同时间点的再生断指组织的基因表达变化进行表征；上述表达变化经定量rtPCR（quantitative rtPCR）分析验证。本数据集包含手术截肢后再生断指以及未接受截肢手术的正常指的小鼠基因表达数据，共计24个样本。上述数据用于筛选两组断指组织间的差异表达基因。