The cKIT kinase inhibitor CHMFL-KIT-64 was used in the treatment of gastrointestinal stromal tumors dataset
收藏科学数据银行2023-02-27 更新2026-04-23 收录
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https://www.scidb.cn/detail?dataSetId=2390c471c86e42bd82902f02ab2e00ab
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资源简介：
Synthesis and characterization of compounds；Antiproliferative effects of compounds CHMFL-KIT-64 against a panel of c-KIT wt/c-KIT-T670I BaF3 cells；Selectivity profiling of compound CHMFL-KIT-64；Antiproliferation effects of compounds antiproliferation efects of compounds CHMFL-KIT-64 against a variety of GIST cancer cell lines；Cellular evaluation of compound CHMFL-KIT-64(for example cell cycle progression, apoptosis and signaling pathways);Antiproliferative effects of compounds CHMFL-KIT-64 against primary cells derived from GIST patients;In vivo PK/PD and efficacy evaluation of compound CHMFL-KIT-64;PK study of compound CHMFL-KIT-64 in mice, sprague dawley rats, and beagle dogs;Antitumor efficacy of CHMFL-KIT-64 in the BaF3-tel-c-KIT-T670I, BaF3-tel-c-KIT-D820G and BaF3-tel-c-KIT-Y823D xenograft mouse model.
提供机构：
Mingfeng Bai; Wenchao Wang; Qingwang Liu; Zhenquan Hu; Yujiao Cai; Fengming Zou; Junjie Wang; Qingsong Liu; Beilei Wang; Ziping Qi; Aoli Wang; Feiyang Liu; Hefei Institutes of Physical Science
创建时间：
2022-10-28
