Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation

Helminth infection leads to lung remodelling. We used single cell ATAC sequencing (scRNA-seq) to analyze the changes in lung cells following exposure to N. brasiliensis at day 28 and day 45 post helminth infection Overall design: Single cell suspension of lungs cells was obtained from pooled samples from controls and helminth exposed mice. CD45+ immune cells were enriched in the pooled samples