Comparative transcription profiling of mRNA and lncRNA related to C75 effect on pulmonary arterial hypertension. Comparative transcription profiling of mRNA and lncRNA related to C75 effect on pulmonary arterial hypertension

Investigated the expression profile and potential roles of mRNA and long non-coding RNAs (lncRNAs) in pulmonary arterial hypertension (PAH) mice induced by monocrotaline. Overall design: Control (n=2), MCT (n=2), and MCT-C75 (n=2) were examined by high throughput sequencing (HTS). Bioinformatics analyses were carried out to predict the roles of aberrantly expressed mRNA and lncRNAs.