SHM hotspot genes in NB, GCB, OCI-Ly1, and OCI-Ly8 cells.

Column 2 lists the genes where non-Ig SHM hotspots were identified. Column 3 shows the novel SNVs identified at the 5′ gene regulatory region of these SHM hotspot genes, the numbers in the parentheses represent the numbers of novel SNVs downstream of TSS. The B-H corrected p values estimating the probability of observing the number of mismatches (column 3) by chance are listed in column 4. Column 5 shows the number of novel SNVs observed in the RGYW motifs, whereas column 6 shows the number of novel SNVs expected in the RGYW motifs given the local sequence context. The Z-score for enrichment of novel SNVs within the RGYW motifs of each non-Ig hotspot is listed in column 7. Column 8 shows the number of novel SNVs observed in WA motifs, whereas column 9 shows the number of novel SNVs expected in WA motifs given the local sequence context. The Z-score for enrichment of novel SNVs within the WA motifs of each non-Ig hotspot is listed in column 10. Column 11 shows the numbers of Transition (Ts) and Transversion (Tv) of novel SNVs in the 5′ regulatory region of each non-Ig hotspot gene.