Conception and Evolution of Stereocontrolled Strategies toward Functionalized 8‑Aryloctanoic Acids Related to the Total Synthesis of Aliskiren
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https://figshare.com/articles/dataset/Conception_and_Evolution_of_Stereocontrolled_Strategies_toward_Functionalized_8_Aryloctanoic_Acids_Related_to_the_Total_Synthesis_of_Aliskiren/2243908
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资源简介：
A detailed
account is given describing the approaches used toward
the total synthesis of aliskiren. In particular, ring-closing metathesis
with the Hoveyda–Grubbs catalyst accelerates the formation
of a 9-membered lactone from an (R)-ester. The diastereomeric
(S)-ester leads to the formation of dimeric dilactones,
which were characterized by X-ray analysis and chemical conversions.
创建时间：
2016-02-16
