Hsd11b1

ENCODES a protein that exhibits NADP binding; steroid binding; 11-beta-hydroxysteroid dehydrogenase (NADP+) activity (ortholog); INVOLVED IN cellular response to estradiol stimulus; glucocorticoid biosynthetic process; glucocorticoid catabolic process; PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH familial hyperlipidemia; Metabolic Syndrome; obesity; FOUND IN apical part of cell; nuclear membrane; endoplasmic reticulum membrane (ortholog); INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 11-dehydrocorticosterone

编码一种具有NADP结合、类固醇结合以及11-β-羟基类固醇脱氢酶（NADP+）活性（同源）的蛋白质；参与细胞对雌二醇刺激的响应；糖皮质激素生物合成过程；糖皮质激素代谢过程；参与11-β-羟基酶缺乏途径；17-α-羟基酶缺乏途径；21-α-羟基酶缺乏途径；与家族性高脂血症、代谢综合征、肥胖相关；存在于细胞顶端部分；核膜；内质网膜（同源）；与（S）-尼古丁、1,1,1-三氯-2,2-双(4-羟基苯基)乙烷、11-脱氢皮质酮相互作用。