Data underlying the research of Changes in gut microbiota and metabolites in patients with Perioperative Neurocognitive Disorder

Perioperative neurocognitive disorder (PND), as a topic of common concern in anesthesia, neuropsychiatry and geriatrics, has been the subject of a wave of research at home and abroad. Patients are focusing more attention on postoperative regression while paying attention to the damage of surgery to the body, which makes the research on brain protection more fruitful. Although there have been a large number of results on postoperative cognition, brain protection starting from the direction of gut microbiota disruption has not yet matured. In this study, we collected fecal samples from surgical patients to examine the abundance and diversity of gut microbiota, and screened different microbiomes and metabolites from samples of PND and performed microbiomics and metabolomics correlation analyses to analyze the correlation between gut microbiota and PND from the perspective of multi-omics and to predict the possible signaling and met albolism pathways, which can be used to provide references for the clinical diagnosis and treatment of PND.

围术期神经认知障碍（Perioperative neurocognitive disorder, PND）作为麻醉学、神经精神病学及老年医学领域的热点议题，已受到国内外学界的广泛研究。患者在关注手术对机体造成损伤的同时，也愈发重视术后认知功能的转归，这使得脑保护相关研究成果日益丰硕。尽管目前术后认知领域已有大量研究成果，但从肠道菌群紊乱方向切入的脑保护研究尚不成熟。本研究收集外科手术患者的粪便样本，以检测肠道菌群的丰度与多样性；同时对围术期神经认知障碍（PND）患者与对照样本中的不同微生物组及代谢物进行筛选，并开展微生物组学与代谢组学关联分析，从多组学视角解析肠道菌群与PND之间的关联，预测潜在的信号通路与代谢通路，以期为PND的临床诊疗提供参考依据。