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Re-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for EwingÂ´s sarcoma

ChEBI2013-07-01 更新2026-07-21 收录

肉瘤靶向治疗

肿瘤基因调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-37409 数据链接链接失效反馈

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Re-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for EwingÂ´s sarcoma

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创建时间：

2013-07-01

肉瘤靶向治疗

FACT复合物

EWS/ETS fusion transcription factors, most commonly EWSR1-FLI1, drive initiation and progression of Ewing sarcoma (EwS), a highly aggressive childhood cancer of bone and soft tissues. Even though dire

NIAID Data Ecosystem100

Reconstructing gene regulatory networks of tumorigenesis [genex]. Homo sapiens

肿瘤基因调控

多组学整合分析

The mechanistic links between transcription factors and the epigenetic landscape, which coordinate the deregulation of gene networks during cell transformation are largely unknown. We used an isogenic

NIAID Data Ecosystem30

Effect of Filip1l down-regulation on gene expression during mouse syngeneic allograft tumor growth.. Effect of Filip1l down-regulation on gene expression during mouse syngeneic allograft tumor growth.

肿瘤基因调控

RNA-seq分析

To investigate downstream pathways affected by Filip1l-knockdown, mTc11 (mouse lung cancer cell line) clones were generated by lentiviral shRNA of either scrambled control or Filip1l. We then performe

NIAID Data Ecosystem20

Supplemental Table 1 from A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

肉瘤靶向治疗

IGF1R抑制剂研究

Related to Figure 1

NIAID Data Ecosystem30

Table_1_Downregulation of ZNF280A inhibits proliferation and tumorigenicity of colorectal cancer cells by promoting the ubiquitination and degradation of RPS14.docx

结直肠癌分子机制

肿瘤基因调控

Colorectal cancer (CRC), one of the cancers with highest mortality, involves complicated molecular mechanisms leading to the onset of malignant phenotypes. ZNF280A, a member of the zinc-finger protein

NIAID Data Ecosystem30

Re-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for EwingÂ´s sarcoma

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