Multivariate analyses of the risk factors for patient and technique survival using Cox's models with repeatedly measured time-dependent covariates.

NOTES. Conversion factors for units: HDL in mg/dL to mmol/L, ×0.02586; urea nitrogen in mg/dL to mmol/L, ×0.357; creatinine in mg/dL to µmol/L, ×88.4.Abbreviations: HDL, high-density lipoprotein cholesterol.1Cox's model with 4 repeatedly measured time-dependent covariates (glucose concentration, weekly renal Kt/V, blood urea nitrogen, and creatinine), adjusted generalized R2 = 0.58.2Cox's model with 7 repeatedly measured time-dependent covariates (diabetes mellitus, glucose concentration, glucose weight, icodextrin solution, weekly renal Kt/V, weekly peritoneal Kt/V, and HDL), adjusted generalized R2 = 0.31.*Each subject's dialysate prescription was represented by (1) the accumulative glucose exposure and (2) the accumulative volumes of icodextrin solution, from the time of PD initiation to each time at which a PD technique failure or death occurred in the Cox's models for PD technique failure or mortality.