Cytokine, metabolite and metal profiles of tumours in serum from breast cancer patients

This study characterised three different classes of biological data measured in the serum of test subjects: metabolites, cytokines, and selected trace metals. Measurements were determined from individuals living with breast cancer diagnosed with invasive ductal carcinoma (n=21) and matched control subjects (n=13). Global untargeted metabolomics analysis of the controls and the subject group identified dysregulated pathways between the subject groups. Additional bioinformatic analyses highlighted unique data features proposed to have further clinical utility. Furthermore, this study highlighted the value provided by open-source research software, which offers ease of access to advanced and niche data analytics in research.

本研究对受试者血清中测量的三种不同类别的生物数据进行特征描述：代谢物、细胞因子和选定的微量元素。测量数据来自21名患有浸润性导管癌（n=21）的乳腺癌患者及其匹配的对照组受试者（n=13）。对对照组和受试组进行的全局非靶向代谢组学分析，揭示了受试组之间的失调通路。额外的生物信息学分析突出了具有进一步临床应用价值的数据特征。此外，本研究强调了开源研究软件所提供的价值，该软件为研究提供了便捷访问先进和特定数据分析的手段。