Clinical and immunohistochemical data of LV cases

We believe inflammation is a significant factor in LV pathogenesis. Consequently, a preliminary comparative study was conducted on the histopathological slides of certain LV patients admitted to our institution, utilizing immunohistochemistry and other methods to explore this aspect further. We gathered clinical data from 36 patients diagnosed with Livedoid vasculopathy (LV) from the electronic medical records of the Department of Dermatology and Venereology at the First Affiliated Hospital of Guangxi Medical University, spanning January 2019 to December 2023. The dataset included detailed information on patient characteristics such as gender, age, timing of disease onset, predilection sites, disease progression, cutaneous manifestations, preexisting comorbidities, diagnostic laboratory findings, histopathological results, instances of misdiagnosis, and established treatment protocols. All participants had complete and thorough clinical profiles. We make a comprehensive statistical analysis performed on this clinical data. And ten tissue paraffin blocks from randomly selected LV patients were subjected to immunohistochemical analysis to detect the expression of CD3, CD4, CD8, CD20, STAT6, MPO, and MBP. An analysis of immune inflammatory infiltrates was also conducted, using tissue specimens from patients with allergic purpura as a control group. This study confirms that the clinical features of Livedoid vasculopathy (LV) are consistent with previously documented findings. Pathological histological examination identified lymphocytic infiltration as a distinguishing feature of LV. Immunohistochemical analyses revealed that inflammation, particularly involving T-lymphocytes, is central to the pathogenesis of LV. The study also found significant expression of STAT6 in dermal inflammatory cells, suggesting its role in promoting inflammation through the STAT6 signaling pathway.