Dataset from Genetic and Environmental Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

The overall objectives of this BETRNet Research Center (RC) are:

1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in
Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA)

2. to increase the biological understanding of key observations made by our clinical
researchers;

3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to
solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in
order to prevent EAC and improve the outcomes of EAC;

4. to foster a transdisciplinary and translation research culture and to effectively expand
and enhance scientific research focused on BE and EAC;

5. to evaluate research and transdisciplinary programs and to continuously improve
research, productivity and enhance translational implementation. These objectives build
and synergize on existing multi-institutional collaborative networks and the
considerable clinical, basic science, and translational expertise available at our
institutions, focusing on improving the outcomes of patients with BE and EAC. The
overarching organization framework for this RC proposal is 1) to focus laboratory
research on understanding the genetic susceptibility, genomic and epigenetic changes
that influence the development of BE and EAC; and 2) to then translate
laboratorydiscoveries into clinical applications for effective detection, molecular risk
stratification, and prevention of progression from BE to EAC.