Hereditary Causes of Nephrolithaisis and Kidney Failure - RKSC 6401. Hereditary Causes of Nephrolithaisis and Kidney Failure - RKSC 6401

Primary hyperoxaluria (PH), cystinuria, adenine phosphoribosyltransferase (APRT) deficiency, and Dent disease are rare inherited (genetic) disorders. These disorders are associated with kidney stone formation and kidney damage. The Rare Kidney Stone Consortium is studying these disorders to better understand how they affect patients. The overall goal of these studies is to develop new treatments to reduce kidney stone formation and the risk of kidney damage. The goal is to enroll 730 patients over five years. Each patient who enrolls will give permission for researchers to review their medical records and to enter some of their health information into a database. In the database, a code number will be used to identify participants. Each patient's progress will then be tracked by reviewing medical records at least once each year for up to the 5 years of the study.