Basigin interactions

Basigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interactions involved in various immunologic phenomena, differentiation, and development, but a major function of basigin is stimulation of synthesis of several matrix metalloproteinases. Basigin also induces angiogenesis via stimulation of VEGF production.<br>Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis.

Basigin是一种在细胞膜上广泛表达的跨膜糖蛋白，属于Ig超家族，且在上皮细胞表面高度富集。Basigin参与涉及多种免疫学现象、分化与发育的细胞间相互作用，但其主要功能是刺激多种基质金属蛋白酶的合成。Basigin还通过刺激VEGF的产生诱导血管生成。Basigin具有一个细胞外区域，其中包含两个Ig样结构域，其中N端Ig样结构域参与相互作用。它在相对细胞或邻近细胞上的Basigin分子之间发生相互作用。此外，它还与多种其他蛋白质相互作用，如caveolin-1、环孢素、整合素和annexin II等，这些蛋白质在细胞增殖、能量代谢、迁移、粘附和运动中扮演着重要角色，特别是在癌症转移中。