Bisphosphonylallenes as Suitable Scaffolds for Unprecedented 4,5-Diphosphonyldihydropyridazines and 3,4-Diphosphonylpyrroles Displaying Antimelanoma Activity

An efficient and simple approach has been developed for
the synthesis
of unprecedented 4,5-diphosphonyldihydropyridazines and 3,4-diphosphonylpyrroles,
through the condensation of bisphosphonylallenes with hydrazines and
primary amines, respectively. The reactions proceed under operationally
simple, mild, and catalyst-free conditions, for a wide substrate scope.
The synthesized compounds were screened for their antiproliferative
activity against melanoma cancer cells, and they showed promising
growth inhibition.