Definition of positive samples according to the cut-off for NAb positivity in different cohorts.

For MPA, MGA, iLite, CPE and LUC assay the cut-off values are presented in ten-fold reduction units per milliliter (TRU/ml). For the In Vivo assay, a sample is considered positive for biologically active antibodies if the MxA induction is decreased by more than 50% compared to antibody-negative controls.