Effect of depletion of TAS1R3 on testicular gene expression in mice fed long-term western diet

Recent studies suggest that the western diet negatively affects male reproduction, but few underlying molecular mechanisms have been established. Also, several studies have reported TAS1R3 is expressed in testis, epididymis and sperm, but their role in male reproduction remains unknown. To investigate the function of taste receptor TAS1R3 in the male reproductive function under western diet condition, we performed RNA-sequencing analysis on testes from C57BL/6 mice fed long-term (18 weeks) western diet. Overall design: Comparative gene expression profiling analysis of RNA-seq data for testes from Tas1r3+/+ and Tas1r3-/- mice fed long-term western diet