Hydrogen-Bond-Mediated Cascade Reaction Involving Chalcones: Facile Synthesis of Enantioenriched Trisubstituted Tetrahydrothiophenes
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https://figshare.com/articles/dataset/Hydrogen_Bond_Mediated_Cascade_Reaction_Involving_Chalcones_Facile_Synthesis_of_Enantioenriched_Trisubstituted_Tetrahydrothiophenes/2549458
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资源简介：
A bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction between 1,4-dithiane-2,5-diol and chalcones with a low catalyst loading has been developed. Trisubstituted tetrahydrothiophenes with three contiguous stereogenic centers are obtained in a highly stereocontrolled manner. Additionally, a remarkable temperature effect on reaction efficiency was observed and a synthetically potential gram-synthesis was also conducted.
创建时间：
2016-02-22
