SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response

After exposing a panel of non-small cell lung cancer (NSCLC) cell lines to cytotoxic CD8+ T-cells, we found SERPINB9 to be the most differentially expressed gene between the cell lines most and least resistant to T-cell killing. Overall design: Gene expression profiling (RNAseq) of a NSCLC cell line panel pre- and post-T-cell exposure as well as concordant pre- and post-cytotoxic T-cell samples.