Additional file 1 of Curation of the Fasciola hepatica kinome as a resource for drug target discovery

Additional file 1: Supplementary data 1. XLSX file containing supplementary tables 1–12 presenting the Fasciola hepatica kinome. Table S1: The F. hepatica kinome, kinome classification, amino acid sequences as well as functional annotations with InterPro, Pfam and SUPERFAMILY domain ID and their description, KEGG terms as well as their definitions. Table S2: Curated F. hepatica protein sequences with assignment of PK families based on phylogenetic analysis. Tables S3−12: Closest homolog of F. hepatica in S. mansoni, S. haematobium and H. sapiens kinomes based on global pairwise analysis results via EMBOSS needle for the PK domains in the PK groups AGC (S3), Atypical PKs (S4), CAMK (S5), CK1 (S6), CMGC (S7), Others (S8), RGC (S9), STE (S10), TK (S11), TKL (12). Identity and similarity (in %) of similar regions in the protein kinase domain sequences of genes with highest bit-scores compared to the F. hepatica gene are indicated, with an exception of using full length sequences instead of PK domains for Atypical PKs. Note that the genes are not necessarily orthologous genes. In case no homolog was identified (NA), results of an additional BLAST search with full-length kinase sequences are presented.