Relative potency for the induction of PXR, VDR and FXR target genes by PCN and LCA.
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N.D. = Not induction observed. Quadruplicate cultures of primary rate hepatocytes were exposed to varying concentrations of PCN or LCA for 48 hours. RNA was extracted and target gene expression measured at the transcript level using TaqMan Q-PCR. Dose response curves were fitted using GraphPad Prism (v5) and EC50 values derived. N.D. = not determined as no dose response relationship evident.
创建时间：
2015-12-02
