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<b>Research Background</b>: Septic shock is a life-threatening condition caused by severe infection, particularly dangerous in children with high mortality and complication rates. Blood purification is an emerging treatment method that helps control infection and improve patient outcomes by removing toxins and inflammatory factors from the body. However, the efficacy of treatment is still controversial.Common blood purification methods include CVVHDF and HP. CVVHDF primarily removes medium and small molecular substances, while HP can directly adsorb and remove large molecular inflammatory factors. <b>Research Objective</b>: This study aims to evaluate the efficacy of blood purification treatment (including CVVHDF combined with HP) in children with septic shock, focusing on the removal of inflammatory factors and its impact on prognosis.<b>Research Methods</b>: The study included 66 children diagnosed with septic shock, divided into a blood purification treatment group and a conventional treatment group. Comparative analysis was conducted on the changes in inflammatory factors before and after treatment, 28-day mortality rate,etc.<b>Research Results</b>: The results showed that the levels of inflammatory factors significantly decreased in the blood purification treatment group after treatment, with a notable reduction in hospitalization and ICU stay duration compared to the conventional treatment group. The 28-day mortality rate was also significantly lower in the blood purification treatment group.<b>Research Conclusion</b>: Blood purification treatment has a significant advantage in quickly and effectively removing inflammatory factors in children with septic shock, reducing mortality, and improving prognosis. Therefore, it is recommended to initiate blood purification treatment for children with septic shock to improve treatment outcomes.<br><br><br><br><br><br>