LncRNAs differentially expressed in PD leukocytes.

Differentially expressed lncRNAs in PD leukocytes compared to HC. Among all the leukocyte RNA-Seq detected lncRNAs, 13 exhibited differential expression in PD patients compared to matched control volunteers (FDR<0.05). Of these, 8 exhibited disease-mediated decrease, and 5- increase. For each lncRNA, given are is ensEMBL transcript ID, log fold change in PD (pre-DBS) compared to HC, FDR and chromosomal location, as well as the average count read, and count per million (CPM) in the leukocyte sequenced libraries. The brain CPM values are given as well where detected. The predicted targeted miRNAs for the 2 PD leukocyte modified possible competitive endogenous lncRNAs (ceRNAs) - the U1 small nuclear ribonucleic particle (snRNP) spliceosome component and RP11-462G22.1 (marked with *) are: for U1 - hsa-miR-188-3p, hsa-miR-512-3p, hsa-miR-125b-5p, hsa-miR-1281, hsa-miR-5091, hsa-miR-4254, hsa-miR-125a-5p, hsa-miR-4319, and for RP11-462G22.1 - hsa-miR-5093, hsa-miR-877-3p, hsa-miR-27b-5p, hsa-miR-4695-5p, hsa-miR-539-5p, hsa-miR-25-5p, hsa-miR-4730, hsa-miR-4727-3p, hsa-miR-1277-5p, hsa-miR-4307, hsa-miR-29b-2-5p, hsa-miR-3142, hsa-miR-4446-5p, hsa-miR-548t-5p, hsa-miR-3922-5p, hsa-miR-769-5p, hsa-miR-3662, hsa-miR-650, hsa-miR-139-5p, hsa-miR-4494, hsa-miR-3612. Bold: lncRNAs that were also detected as altered in RNA-Seq data from PD patients' brain samples as compared with HC brains.
#: validated by qRT-PCR in both PD leukocytes and 2 brain regions (Amygdala and Substantia Nigra) of PD and unaffected individuals (the Netherlands Brain Bank).