Sequence variants within the coding regions of candidate genes that influence the metabolomic levels independent of the GWAS hits.

A1; affect allele, A2; other allele, beta; effect estimate, SE; standard error of beta, P-value a; p value of the association between the SNP and the metabolite, P-value b; p-value of the association between the SNP and the metabolite, adjusted by the GWAS SNP, P-value c; p-value of the association between the GWAS SNP and the metabolite, adjusted by the SNP.*Loci in which the GWAS is explained by the SNPs within the genes. Selection of significance for SNPs is based on P-value b. Chr; chromosome; LD; linkage disequilibrium; MAF; minor allele frequency; SNP; single nucleotide polymorphism; eQTL; expression quantitative trait loci.
Sequence variants within the coding regions of candidate genes that influence the metabolomic levels independent of the GWAS hits.