Transcriptional profile of MORC3 deficient BLaER1 monocytes [KO]

We have identified MORC3 as a negative regulator of Type I Interferon (IFN), whose absence induces IFN and interferon-stimulated genes (ISGs). To study the global transcriptional effects of loss of MORC3, we deleted MORC3 in WT, IFNAR1–/– IFNAR2–/– and IFNB1–/– BLaER1 monocytes and performed RNA-seq. Overall design: Monoclonal gene-deficient BLaER1 monocytes in three independent experiments.