Flortaucipir PET uncovers relationships between tau and β-amyloid in aging, primary age related tauopathy, and Alzheimer disease

[18F]-Flortaucipir PET is considered a good biomarker of Alzheimer’s disease. However, it is unknown how flortaucipir is associated with the distribution of tau across brain regions and how these associations are influenced by β-amyloid. It is also unclear whether flortaucipir can detect tau in definite primary age-related tauopathy (PART). We identified 248 individuals at Mayo Clinic that had undergone [18F]-flortaucipir PET during life, had died, and undergone an autopsy, 239 cases of which also had β-amyloid PET. We assessed nonlinear relationships between flortaucipir uptake in nine medial temporal and cortical regions, Braak tau stage and Thal β-amyloid phase using generalized additive models. We found that flortaucipir uptake was greater with increasing tau stage in all regions. Increased uptake at low tau stages in medial temporal regions was only observed in cases with high β-amyloid phase. Flortaucipir uptake linearly increased with β-amyloid phase in medial temporal and cortic..., These data are from 248 participants recruited from Mayo Clinic, Rochester, MN, who had flortaucipir PET imaging during life, had died, and had undergone an autopsy evaluation. All patients were enrolled into one of three NIH funded cohort studies including the Mayo Clinic Alzheimer’s Disease Research Center (PI: Petersen), The Mayo Clinic Study of Aging (PI: Petersen) and the Neurodegenerative Research Group (PIs: Josephs/Whitwell)., , # Data sets for \"Flortaucipir PET uncovers relationships between tau and β-amyloid in aging, primary age related tauopathy, and Alzheimer disease\"

Each of these file corresponds to a figure in the main paper or in the supplementary materials.

## `figure1.csv`

* `Thal` is Thal phase which is measured by histopathology. This is an
ordinal variable with no units.
* `Braak` is Braak neurofibrillary tangle stage. This is an ordinal
variable with no units. Braak stages are sometimes styled using Roman
numerals.
* `Group` is a composite variable representing how we combined Thal
phase and Braak stage.

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## `figure2.csv`

* `region` is the location in the brain where the flortaucipir PET
tracer was measured. The regions are as follows:
1. ERC, entorhinal cortex
2. Anterior HP or AHP, anterior hippocampus
3. Fusiform or FFG, fusiform gyrus
4. Inferior temporal or ITG, inferior temporal gyrus
5. Superior frontal or SFG, superior frontal gyrus
6. Precuneus or PRCU, pr...