Co-clinical analysis of a genetically-engineered mouse model and human prostate cancer reveals significance of NKX3.1 expression for response to 5a-reductase inhibition (Mouse Finasteride Prostate RNASeq)

Analysis of transcriptome from 12 month old finasteride (and vehicle) treated mouse prostatic tissue Prostate tissue from 12 month old Nkx3.1+/+ and Nkx3.1-/- mice treated with finasteride (or vehicle) was harvested, and snap frozen for subsequent molecular analysis Overall design: Total RNA obtained from prostate tissues. Prostate tissues were harvested and processed for RNA isolation and transcriptome analysis using the MagMAX RNA isolation kit (Ambion).