RUNX3 regulates YAP1-mediated transcription

Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).

RUNX3与TEADs:YAP1复合物的关联：RUNX3对TEADs:YAP1复合物结合至CTGF启动子的过程具有抑制作用，进而负向调控CTGF基因的转录，该基因编码的为结缔组织生长因子（Yagi等，1999年，Zhao等，2008年，Qiao等，2016年）。