4(N)-ARYL/ALKYL SUBSTITUTED THIOSEMICARBAZONE DERIVED METAL COMPLEXES, THEIR SPECTRAL AND BIOCHEMICAL STUDIES: A REVIEW

N(4)-alkyl/aryl substituted thiosemicarbazones and their metal complexes show significantly enhanced biochemical properties than well-known standard drugs. In this review, we extensively focused on the synthesis, biological applications, and structural characterization of the aforementioned compounds over the past decade. A detailed description of the structures of thiosemicarbazone derivatives substituted at the N(4)-position and their metal complexes is presented here. The structures of the compounds were elucidated with respect to their bonding interactions with metal ions and their geometric configurations. Additionally, the review emphasizes the importance of ligands and complexes by reviewing their biological and analytical applications, such as the newly discovered N(4)-substituted thiosemicarbazones and metal chelates throughout the previous decade. It highlights their potential impact on future research and practical applications.