Genomic validation of the revised Bethesda criteria in terms of pathogenesis and oncologic significance

To know genomic alterations of the respective situation of the revised Bethesda criteria, we investigated the impact of somatic variants and gene expression using colorectal tumor tissues. Using Exome-seq and RNAseq analysis, we identified novel somatic variants that are significantly associated with Bethesda criteria. Using the markers, we predicted the the therapeutic target of familial colorectal cancer. This series includes only the RNA-seq data. Overall design: RNA-seq of 98 colorectal tumor tissues