Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA

This entry contains raw sequencing data in FASTQ format generated from e2MPRA experiments conducted in the HepG2 and WTC11 cell line . e2MPRA is a high-throughput method designed to quantify the transcriptional and epigenetic regulatory activities of cis-regulatory elements (CREs) in parallel. The dataset includes results from three libraries: a pilot library, a HepG2 synthetic CRE library, and a WTC11 enhancer perturbation libary, tested using lentiMPRA, ATAC-seq, and H3K27ac CUT&Tag-seq to characterize various aspects of the epigenetic activity of the library sequences.