Chikungunya Virus Time Course Infection of Human Macrophages

Human monocyte-derived macrophage cells were infected with Chikungunya virus (CHIKV) to identify and quantify intracellular transcriptional changes that contribute to the host response to infection with CHIKV. RNA was collected from these cells at 8 and 24 hours post-infection (hpi) and were compared to mock-infected cells. The RNAseq data was then analyzed to determine the genes, functions, and signaling pathways that were significantly affected in an effort to predict existing drugs that could be repurposed as potential therapeutics for CHIKV. Overall design: mRNA profiles of human monocyte-derived macrophages at 8hpi and 24hpi with Chikungunya virus (CHIKV)