Adjusted incidence rate ratios of failure, relapse, and acquired drug resistance (from negative binomial regression).

aAcquired drug resistance in both failure and relapse cases combined.bAdjusted estimates of Incidence Rate Ratios (IRR) from multivariate negative binomial regression with model that included all variables indicated, plus length of follow-up after end of treatment (for relapse and acquired drug resistance), supervision of therapy (DOT), and non-completion of therapy because of protocol violations, patient refusal, default, moved, or lost. Estimates that are statistically significant are in bold.cOverall significance of each factor in multi-variate models, from log likelihood ratio test.dAdjusted estimates of IRR from second model that included initial drug resistance, and all the same factors, but not the number of sensitive drugs in initial or continuation phases. These could not be included because of substantial co-linearity with drug resistance.