Polycomb-like 2 associates with PRC2 and is required for mouse embryonic stem cell

ChEBI2010-02-22 更新2026-07-21 收录

表观遗传调控

干细胞生物学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-16364 数据链接链接失效反馈

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Polycomb-like 2 associates with PRC2 and is required for mouse embryonic stem cell

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2010-02-22

DNA dioxygenases Tet2/3 control epithelial differentiation [RNA-seq]

毛囊上皮分化

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Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes catalyzing 5-methylcytosine oxidation

Alliance of Genome Resources00

An epigenetic switch in vascular phenotype augments anti-tumor immunity [bulkRNA-seq]

肿瘤免疫微环境

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The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that targeting the e

NIAID Data Ecosystem00

Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells. Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells

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肾病与白血病基因功能研究

To examine if loss of FIS1 would alter the H3K27Ac status of leukemic cells, we used shRNA to knock down the expression of FIS1 in leukemic cell line MOLM-13 cells and performed H3K27Ac CHIP-seq to ch

NIAID Data Ecosystem00

DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

Stage-specific Kdm6b-transcription factor partnerships orchestrate temporal precision during stepwise motor neuron differentiation [RNA-seq]

运动神经元

表观遗传调控

Histone modifiers instruct cellular differentiation, yet how they achieve temporal precision remains enigmatic. Here we demonstrate that the H3K27 demethylase Kdm6b acts as a master epigenetic conduct

NIAID Data Ecosystem00

Polycomb-like 2 associates with PRC2 and is required for mouse embryonic stem cell

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