Hepatocyte nuclear factor 4alpha (HNF4α) is a nuclear receptor with an emerging role in the gut. While HNF4α has been implicated in colitis and colon cancer in humans, deciphering its functional role
Colorectal cancer (CRC) is a major public health concern and disproportionately impacts racial/ethnic minority populations in the U.S. Animal models are helpful in examining human health disparities b
This model looks at the development of colitis-associated colon cancer in order investigate the mechanism behind inflammation-associated tumorigenesis. Dynamic simulations reveal that P53, MDM2, and A
Colorectal cancer (CRC) is a major public health concern and disproportionately impacts racial/ethnic minority populations in the U.S. Animal models are helpful in examining human health disparities b