STIM1 oligomerizes

In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).

在静息状态下，STIM1的管腔域在质膜内与Ca2+离子结合，此种结合防止了STIM1的二聚化（Luik等，2008）。当质膜内的Ca2+离子耗尽后，STIM1不再与Ca2+结合，并形成同源二聚体（Muik等，2008，Luik等，2008，Park等，2009）。