Phosphorylation of Bcl10

Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.

在与CARMA1相互作用后，Bcl10发生磷酸化和寡聚化。寡聚化的Bcl10充当MALT1和TRAF6进入的适配器。Bcl10的磷酸化事件可以正负双向调节NF-kB通路。依赖于Ser/Thr激酶RIP2并与其物理结合的Bcl10磷酸化具有激活NF-kB通路的作用。RIP2介导的磷酸化作用的目标位点尚未确定。