Collection of Tissue and Blood Specimens and Clinical Data from Patients with Suspected Gynecological Neoplasms and Patients with Gynecological Cancers

This study characterized the evolution of the peripheral immune cell function and composition across the course of standard of care platinum and taxane chemotherapy in ovarian cancer using bulk and single cell transcriptomic approaches. Serial blood samples were collected from ten patients with advanced high-grade serous ovarian cancer treated with chemotherapy. Single cell sequencing was performed on five patients_ samples collected before the initiation of chemotherapy and after the third cycle of chemotherapy.