Polymicrobial biofilm interaction between Histophilus somni and Pasteurella multocida

Histophilus somni and Pasteurella multocida, in conjunction with various viruses, cause bovine respiratory disease (BRD) in cattle. Following respiratory infection of calves with H. somni, P. multocida may also be isolated from the lower respiratory tract. Because H. somni may form a biofilm during BRD, we sought to determine if P. multocida can co-exist with H. somni in a polymicrobial biofilm in vitro and in vivo.