Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats [human]

We investigated mRNA expression levels in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients, after no treatment, or after ginsenoside CK or dexamethasone treatment. The aim of the study was to determine the differences in the effects of ginsenoside CK and dexamethasone on mRNA levels in RA-FLS. Both ginsenoside CK and dexamethasone regulate some of the same inflammatory genes. Overall design: We investigated mRNA expression levels in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients, after no treatment, or after ginsenoside CK or dexamethasone treatment.