PCBP4 modulates CDKN1A translation

PCBP4 binding to the 3'-UTR of the CDKN1A (p21) mRNA reduces half-life of the CDKN1A mRNA and the amount of CDKN1A protein. Upon DNA damage, TP53-mediated induction of CDKN1A is rapid, while the induction of PCBP4 is more gradual. It is hypothesized that, under prolonged stress, PCBP4-mediated down-regulation of CDKN1A may switch from G1 cell cycle arrest to G2 arrest, which may precede apoptosis (Scoumanne et al. 2011).

PCBP4与CDKN1A（p21）mRNA的3'-非编码区结合，降低CDKN1A mRNA的半衰期及其蛋白的量。在DNA损伤情况下，TP53介导的CDKN1A诱导迅速发生，而PCBP4的诱导则较为缓慢。据此假设，在持续的应激状态下，PCBP4介导的CDKN1A下调可能从G1期细胞周期阻滞转变为G2期阻滞，这一过程可能预示着细胞凋亡的发生（Scoumanne等，2011年）。