CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

Kras and Trp53 mutations promote transformation in pancreatic acinar and ductal cells. We wanted to evaluate whole transcriptomic profiles of acinar and ductal derived tumors. In addition, we studied whole transcriptomic changes in ex vivo cultured ducts expressing mutant Kras compared to control ducts. Mutant Kras and mutant Trp53 were genetically deleted from acinar or ductal cells using inducible CRE:ER alleles. Eight week old mice were given tamoxifen (5mg) in corn oil and mice were monitored for signs of disease progression.