Identification of 5'isomiR in HCC patients.
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https://www.ncbi.nlm.nih.gov/sra/SRP320296
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资源简介：
The microRNA (miRNA) processing is a critical step for production of mature miRNAs. Its dysregulation leads to the increase of miRNA isoforms with heterogenous 5' ends (isomiRs), recognizing distinct target sites with a shifted seed sequence. Although some miRNA genes display productive expression of their 5'-isomiRs in cancers, how the production is controlled and how they impact on tumor progression are unexplored yet. In this study, we identified tumor-specific production of isomiRs and investigated biological function of isomiRs in liver cancer. Overall design: 15 Normal liver (NL), 60 HCC (TG1=10, TG2=25, TG3=19, HPC=6) samples who underwent small RNA-Seq
创建时间：
2023-06-02
