CYP4F11 16-hydroxylates 3OH-PALM

Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).

长链3-羟基脂肪酸（3OHFAs）在人类肝脏中经ω-羟基化形成3-羟基二羧酸（3OHDCAs）的前体。这些产物可能与脂肪酸动员或线粒体脂肪酸β-氧化受损导致3-OHFA水平升高的病理状态有关。孤儿P450酶CYP4A11已被证实能够分别将3-羟基硬脂酸和3-羟基棕榈酸（3OH-PALM）18-羟基化和16-羟基化，形成ω-羟基化前体；后者在本研究中得以证实（Dhar等人，2008年）。