Allelic effects and transmission of QTLs mapped in the PVGBC population.

QTLs are indicated with chromosome: location in Mb, * indicates QTLs that are shared between DABC and PVGBC populations. The p-values from effect plots in PVGBC are given, analyzed by Student's t-test, p-values ≤0.05 were considered significant. a Onset and incidence gave similar results and ONS is shown as a representative for susceptibility phenotypes. b Maximum and cumulative EAE scores and duration of EAE showed similar results and MAX represents the severity phenotypes. QTLs on chromosome 5a (25 Mb) and 13 (58 Mb) (Table S1) were significant only in the entire PVGBC and were therefore taken out of the table. Bold indicates significant p-values for QTLs showing evidence for parent-of-origin dependence. Abbreviations: ONS  =  onset of EAE, MAX  =  maximum EAE score, WL  =  weight loss, Allele  =  disease predisposing allele, D  =  DA, P  =  PVG, Trans  =  transmission of disease-predisposing allele, Cross  =  indicates reciprocal cross in which QTL was identified, Mat  =  maternal transmission, Pat  =  paternal transmission and Mito  =  mitochondria.