Metagenomics and metatranscriptomics of WT and Down Syndrome model (Ts65Dn) mice fed control and High-fat diet, sequenced with Illumina HiSeq (total RNA and ribodepleted RNA).. Metagenomics and metatranscriptomics of microbiome of Ts65Dn (Down Syndrome model) and WT mice on control and high-fat diet sequenced with Illumina HiSeq (total RNA and ribodepleted RNA).

Recent studies have implicated dysbiosis of gut microbiota in several central nervous system (CNS) disorders, including Down syndrome (DS). Here, we studied the faecal metatranscriptomes of the DS model Ts65Dn mice, in order to identify the differentially expressed transcripts. The complex symbiotic relationship between the gut microbiome and its host is strongly influenced by diet and nutrition. Given that DS individuals have an increased prevalence of obesity, we also studied the effects of a high-fat diet (HFD) on the transcriptomic changes of mice gut microbiomes, distinguishing the Ts65Dn mice from wild types. Data include the total RNA (mainly rRNA) samples and the ribodepleted ones.