Gene expression in diabetic RIP-LCMV-GP mice. Gene expression in diabetic RIP-LCMV-GP mice

Gene expression profile in laser-dissected islets of Langerhans in the inducible RIP-LCMV-GP mouse model for type 1 diabetes (T1D) RIP-LCMV-GP mice express the glycoprotein (GP) of the lymphocytic choriomeningitis virus (LCMV) in the beta-cells (rat insulin promotor, RIP); T1D develops 10-14 after LCMV-infection Overall design: RNA has been isolated from the entire islet microenvironment (including the cellular infiltrates) before and at several times after diabetes initiation by LCMV infection