Sensitivity of simulated transcranial ultrasound fields to acoustic medium property maps

This data was
collected in order to validate models of ultrasound propagation through skull
bone phantoms.

A single
element spherically focusing ultrasound transducer (PA332 at 1 MHz, Precision
Acoustics) was used to generate an acoustic field. Measurements were performed
with a 0.2 mm PVDF needle hydrophone (Precision Acoustics) to characterise the
source under short burst conditions (3 cycles). These measurements include
planar scans in the prefocal region in free field for characterisation of the
source, and planar scans further from the source after propagation through 3
different bone phantoms: a parametric araldite resin phantom, a mesh based
skull bone phantom obtained from a T1 weighted MRI scan of the head, cast in
araldite and printed in VeroBlack.

Medium maps
used in simulations, which match the experimental set up are included as a
supplementary file, these include speed of sound, attenuation coefficient and
density. The .stl file containing the mesh is also included as a supplementary
file.

All measurements were acquired using an automated
scanning tank filled with degassed, deionised water. The transducer was mounted
in a fixed xyz position. Hydrophones were mounted on an automated xyz stage,
with manual tilt, rotate adjustment.

In total this study contains 5 datasets contained 5 files,
the corresponding figure or table in the paper is given in brackets:

1: Free field XY planar transverse scan at z = 45 mm,
corresponds to dataset 2, which was performed in the same measurement session.

2. XY planar transverse scan at z = 58 mm after
propagation through a parametric araldite 1302 resin phantom. (Fig 13)

3. Free field XY planar transverse scan at 45 mm,
corresponds to datasets 4 and 5, which were performed in the same measurement
session.

4. Planar transverse scan at z = 85 mm after propagation
through a mesh based skull bone phantom cast in araldite 1302. (Fig 14)

5. Planar transverse scan at z = 85 mm after propagation
though a mesh based skull bone phantom printed in VeroBlack. (Fig 14)

Supplementary files:

6. *_supplementary_01.h5, h5 file containing fields
medium1, medium2 and medium3, which contain grid based medium maps (sound
speed, attenuation coefficient at 1 MHz, and density), with coordinates and
description, for medium1: parametric resin phantom, medium2: mesh based resin
phantom, medium3: mesh based VeroBlack phantom.

7. *_supplementary-02.stl, .stl file containing mesh used
to construct the anatomical bone phantom

本研究旨在验证通过颅骨模型进行超声传播的模型。本研究采用单元素球面聚焦超声换能器（PA332，频率为1 MHz，Precision Acoustics）生成声场，并使用0.2 mm PVDF针式水听器（Precision Acoustics）进行测量，以在短脉冲条件下（3个周期）表征声源。测量包括在自由场中针对声源的预先焦点区域的平面扫描，以及通过三个不同骨模型传播后的平面扫描：参数化的阿拉丁树脂模型，基于T1加权头部MRI扫描的网格颅骨模型，浇注于阿拉丁树脂并打印于VeroBlack上。模拟中使用的介质图与实验设置相匹配，包括作为补充文件的声速、衰减系数和密度。还包括用于构建解剖学骨模型的网格.stl文件。所有测量均使用充满脱气、去离子的自动扫描罐进行，换能器固定在xyz位置，水听器安装在自动xyz台上，带有手动倾斜和旋转调整。本研究的总数据集中包含5个数据集，共5个文件，论文中相应的图或表在括号中给出：

1：在z = 45 mm处的自由场XY平面横截面扫描，对应于数据集2，在相同测量会话中执行。

2. 在z = 58 mm处的XY平面横截面扫描，经过参数化阿拉丁树脂1302树脂模型传播。 （图13）

3. 在45 mm处的自由场XY平面横截面扫描，对应于数据集4和5，在相同测量会话中执行。

4. 在z = 85 mm处的平面横截面扫描，经过浇注于阿拉丁树脂1302的基于网格的颅骨模型传播。 （图14）

5. 在z = 85 mm处的平面横截面扫描，经过打印于VeroBlack的基于网格的颅骨模型传播。 （图14）

补充文件：

6. *_supplementary_01.h5，包含medium1、medium2和medium3字段的h5文件，这些字段包含基于网格的介质图（声速、1 MHz的衰减系数和密度），带有坐标和描述，其中medium1：参数化树脂模型，medium2：基于网格的树脂模型，medium3：基于网格的VeroBlack模型。

7. *_supplementary-02.stl，包含用于构建解剖学骨模型的网格的.stl文件。